| PLAYER | G | CMP | ATT | YDS | CMP% | LNG | TD | INT | SCK | QBR |
| Matthew Stafford (LAR) | 17 | 388 | 597 | 4707 | 0.65 | 88 | 46 | 8 | 23 | 109.2 |
| Jared Goff (DET) | 17 | 393 | 578 | 4564 | 0.68 | 64 | 34 | 8 | 38 | 105.5 |
| Dak Prescott (DAL) | 17 | 404 | 600 | 4552 | 0.67 | 86 | 30 | 10 | 31 | 99.5 |
| Drake Maye (NE) | 17 | 354 | 492 | 4394 | 0.72 | 72 | 31 | 8 | 47 | 113.5 |
| Sam Darnold (SEA) | 17 | 323 | 477 | 4048 | 0.68 | 67 | 25 | 14 | 27 | 99.1 |
| Trevor Lawrence (JAX) | 17 | 341 | 560 | 4007 | 0.61 | 63 | 29 | 12 | 41 | 91 |
| Caleb Williams (CHI) | 17 | 330 | 568 | 3942 | 0.58 | 65 | 27 | 7 | 24 | 90.1 |
| Bo Nix (DEN) | 17 | 388 | 612 | 3931 | 0.63 | 52 | 25 | 11 | 22 | 87.8 |
| Justin Herbert (LAC) | 16 | 340 | 512 | 3727 | 0.66 | 60 | 26 | 13 | 54 | 94.1 |
| Baker Mayfield (TB) | 17 | 343 | 543 | 3693 | 0.63 | 77 | 26 | 11 | 36 | 90.6 |
| Josh Allen (BUF) | 17 | 319 | 460 | 3668 | 0.69 | 54 | 25 | 10 | 40 | 102.2 |
| Patrick Mahomes (KC) | 14 | 315 | 502 | 3587 | 0.63 | 61 | 22 | 11 | 34 | 89.6 |
| Jordan Love (GB) | 15 | 291 | 439 | 3381 | 0.66 | 59 | 23 | 6 | 21 | 101.2 |
| Jacoby Brissett (ARI) | 14 | 315 | 485 | 3366 | 0.65 | 50 | 23 | 8 | 43 | 94.1 |
| Aaron Rodgers (PIT) | 16 | 327 | 498 | 3322 | 0.66 | 80 | 24 | 7 | 29 | 94.8 |
| Jalen Hurts (PHI) | 16 | 294 | 454 | 3224 | 0.65 | 79 | 25 | 6 | 32 | 98.5 |
| Cam Ward (TEN) | 17 | 323 | 540 | 3169 | 0.60 | 47 | 15 | 7 | 55 | 80.2 |
| Daniel Jones (IND) | 13 | 261 | 384 | 3101 | 0.68 | 75 | 19 | 8 | 22 | 100.2 |
| C.J. Stroud (HOU) | 14 | 273 | 423 | 3041 | 0.65 | 75 | 19 | 8 | 23 | 92.9 |
| Geno Smith (LV) | 15 | 302 | 448 | 3025 | 0.67 | 61 | 19 | 17 | 55 | 84.7 |
| Bryce Young (CAR) | 16 | 304 | 478 | 3011 | 0.64 | 54 | 23 | 11 | 27 | 87.8 |
| Tua Tagovailoa (MIA) | 14 | 260 | 384 | 2660 | 0.68 | 47 | 20 | 15 | 30 | 88.5 |
| Lamar Jackson (BAL) | 13 | 192 | 302 | 2549 | 0.64 | 64 | 21 | 7 | 36 | 103.8 |
| Joe Flacco (CIN) | 13 | 251 | 416 | 2479 | 0.60 | 44 | 15 | 10 | 18 | 79.2 |
| Tyler Shough (NO) | 11 | 221 | 327 | 2384 | 0.68 | 62 | 10 | 6 | 31 | 91.3 |