| PLAYER | G | CMP | ATT | YDS | CMP% | LNG | TD | INT | SCK | QBR |
| Jordan Love (GB) | 9 | 215 | 341 | 2618 | 0.63 | 81 | 19 | 6 | 17 | 97.9 |
| Joe Burrow (CIN) | 8 | 219 | 296 | 2386 | 0.74 | 47 | 23 | 6 | 15 | 114.8 |
| Dak Prescott (DAL) | 9 | 218 | 336 | 2381 | 0.65 | 53 | 16 | 5 | 14 | 95.3 |
| Matthew Stafford (LAR) | 9 | 230 | 346 | 2374 | 0.66 | 64 | 16 | 9 | 13 | 90.6 |
| Kirk Cousins (LV) | 9 | 202 | 315 | 2340 | 0.64 | 45 | 20 | 8 | 11 | 97.1 |
| Drake Maye (NE) | 9 | 178 | 272 | 2282 | 0.65 | 63 | 18 | 11 | 20 | 96.8 |
| C.J. Stroud (HOU) | 8 | 181 | 282 | 2251 | 0.64 | 63 | 16 | 2 | 16 | 104.8 |
| Bryce Young (CAR) | 8 | 186 | 308 | 2197 | 0.60 | 55 | 16 | 6 | 26 | 91.3 |
| Jared Goff (DET) | 8 | 185 | 273 | 2134 | 0.68 | 57 | 15 | 2 | 19 | 106.4 |
| Geno Smith (NYJ) | 9 | 183 | 271 | 2078 | 0.68 | 60 | 12 | 3 | 28 | 100.5 |
| Patrick Mahomes (KC) | 8 | 177 | 263 | 2037 | 0.67 | 73 | 14 | 4 | 11 | 101.8 |
| Josh Allen (BUF) | 8 | 156 | 236 | 2027 | 0.66 | 57 | 12 | 6 | 17 | 99.3 |
| Tyler Shough (NO) | 8 | 204 | 308 | 1986 | 0.66 | 52 | 14 | 6 | 20 | 91.2 |
| Brock Purdy (SF) | 8 | 163 | 236 | 1980 | 0.69 | 82 | 17 | 5 | 8 | 109.8 |
| Trevor Lawrence (JAX) | 8 | 146 | 224 | 1932 | 0.65 | 52 | 18 | 4 | 13 | 111.7 |
| Aaron Rodgers (PIT) | 8 | 175 | 288 | 1871 | 0.61 | 80 | 13 | 6 | 23 | 86.2 |
| Deshaun Watson (CLE) | 8 | 163 | 249 | 1806 | 0.65 | 60 | 7 | 3 | 33 | 91.2 |
| Bo Nix (DEN) | 9 | 174 | 287 | 1730 | 0.61 | 52 | 11 | 4 | 11 | 84.7 |
| Daniel Jones (IND) | 9 | 182 | 302 | 1722 | 0.60 | 55 | 6 | 10 | 24 | 68.9 |
| Jacoby Brissett (ARI) | 8 | 193 | 305 | 1719 | 0.63 | 38 | 10 | 7 | 19 | 79.7 |
| Justin Herbert (LAC) | 8 | 144 | 235 | 1591 | 0.61 | 58 | 6 | 11 | 31 | 70.4 |
| Caleb Williams (CHI) | 6 | 134 | 195 | 1546 | 0.69 | 58 | 8 | 5 | 14 | 95.4 |
| Cam Ward (TEN) | 8 | 155 | 248 | 1483 | 0.63 | 41 | 6 | 5 | 13 | 78.7 |
| Sam Darnold (SEA) | 7 | 127 | 211 | 1478 | 0.60 | 43 | 10 | 9 | 17 | 79.5 |
| Michael Penix Jr. (ATL) | 7 | 124 | 199 | 1444 | 0.62 | 76 | 10 | 6 | 9 | 88.4 |