| PLAYER | G | ATT | YDS | AVG | LNG | TD | FUM | LST |
| Bijan Robinson (ATL) | 9 | 169 | 880 | 5.2 | 59 | 5 | 2 | 0 |
| Kenneth Walker III (KC) | 8 | 159 | 872 | 5.5 | 76 | 7 | 0 | 0 |
| Jahmyr Gibbs (DET) | 8 | 177 | 847 | 4.8 | 30 | 9 | 1 | 1 |
| Bucky Irving (TB) | 9 | 167 | 825 | 4.9 | 72 | 7 | 3 | 1 |
| James Cook III (BUF) | 8 | 169 | 814 | 4.8 | 35 | 8 | 4 | 2 |
| Jaylen Warren (PIT) | 8 | 119 | 704 | 5.9 | 51 | 2 | 1 | 0 |
| Derrick Henry (BAL) | 9 | 175 | 689 | 3.9 | 32 | 8 | 1 | 1 |
| Jonathan Taylor (IND) | 9 | 161 | 656 | 4.1 | 38 | 8 | 2 | 2 |
| Javonte Williams (DAL) | 9 | 154 | 629 | 4.1 | 34 | 9 | 2 | 0 |
| Chuba Hubbard (CAR) | 8 | 134 | 619 | 4.6 | 32 | 5 | 1 | 0 |
| Braelon Allen (NYJ) | 9 | 120 | 598 | 5.0 | 27 | 3 | 2 | 1 |
| Tony Pollard (TEN) | 8 | 133 | 595 | 4.5 | 40 | 6 | 1 | 0 |
| Kyren Williams (LAR) | 9 | 127 | 593 | 4.7 | 30 | 6 | 2 | 2 |
| D'Andre Swift (CHI) | 9 | 155 | 576 | 3.7 | 32 | 10 | 2 | 2 |
| Bhayshul Tuten (JAX) | 8 | 122 | 521 | 4.3 | 39 | 4 | 0 | 0 |
| Aaron Jones Sr. (MIN) | 8 | 115 | 474 | 4.1 | 20 | 2 | 1 | 1 |
| Ollie Gordon II (MIA) | 8 | 107 | 463 | 4.3 | 53 | 4 | 0 | 0 |
| Christian McCaffrey (SF) | 8 | 102 | 457 | 4.5 | 16 | 9 | 0 | 0 |
| Blake Corum (LAR) | 9 | 86 | 447 | 5.2 | 23 | 4 | 1 | 0 |
| Cam Skattebo (NYG) | 7 | 98 | 418 | 4.3 | 42 | 2 | 3 | 1 |
| Emanuel Wilson (SEA) | 8 | 111 | 403 | 3.6 | 21 | 3 | 2 | 1 |
| Rhamondre Stevenson (NE) | 9 | 102 | 399 | 3.9 | 24 | 2 | 0 | 0 |
| Chase Brown (CIN) | 8 | 103 | 397 | 3.9 | 19 | 1 | 1 | 1 |
| Quinshon Judkins (CLE) | 8 | 116 | 385 | 3.3 | 30 | 3 | 0 | 0 |
| Omarion Hampton (LAC) | 8 | 102 | 369 | 3.6 | 32 | 3 | 2 | 2 |