| PLAYER | G | ATT | YDS | AVG | LNG | TD | FUM | LST |
| Bijan Robinson (ATL) | 3 | 66 | 349 | 5.3 | 55 | 2 | 1 | 0 |
| Kenneth Walker III (KC) | 2 | 47 | 290 | 6.2 | 60 | 1 | 0 | 0 |
| Derrick Henry (BAL) | 2 | 40 | 212 | 5.3 | 32 | 4 | 0 | 0 |
| Jahmyr Gibbs (DET) | 2 | 45 | 208 | 4.6 | 21 | 2 | 0 | 0 |
| James Cook III (BUF) | 2 | 34 | 192 | 5.6 | 35 | 1 | 1 | 0 |
| Jonathan Taylor (IND) | 2 | 43 | 190 | 4.4 | 24 | 4 | 0 | 0 |
| D'Andre Swift (CHI) | 2 | 34 | 169 | 5.0 | 32 | 3 | 1 | 1 |
| Ashton Jeanty (LV) | 2 | 44 | 150 | 3.4 | 15 | 0 | 0 | 0 |
| Kyle Monangai (CHI) | 2 | 20 | 147 | 7.4 | 61 | 1 | 0 | 0 |
| Aaron Jones Sr. (MIN) | 2 | 35 | 145 | 4.1 | 20 | 1 | 0 | 0 |
| Omarion Hampton (LAC) | 2 | 35 | 137 | 3.9 | 17 | 2 | 2 | 2 |
| Chase Brown (CIN) | 2 | 36 | 136 | 3.8 | 13 | 1 | 0 | 0 |
| Bucky Irving (TB) | 2 | 25 | 134 | 5.4 | 38 | 1 | 0 | 0 |
| Blake Corum (LAR) | 2 | 22 | 133 | 6.0 | 18 | 0 | 1 | 0 |
| Brian Robinson Jr. (ATL) | 3 | 30 | 132 | 4.4 | 16 | 1 | 0 | 0 |
| Breece Hall (NYJ) | 2 | 38 | 131 | 3.4 | 14 | 1 | 0 | 0 |
| Bhayshul Tuten (JAX) | 2 | 28 | 131 | 4.7 | 16 | 1 | 0 | 0 |
| Kyren Williams (LAR) | 2 | 23 | 126 | 5.5 | 20 | 1 | 1 | 1 |
| Cam Skattebo (NYG) | 2 | 30 | 117 | 3.9 | 13 | 1 | 1 | 0 |
| De'Von Achane (MIA) | 2 | 31 | 110 | 3.5 | 17 | 0 | 0 | 0 |
| Caleb Williams (CHI) | 2 | 15 | 107 | 7.1 | 29 | 2 | 0 | 0 |
| Jacory Croskey-Merritt (WSH) | 2 | 28 | 106 | 3.8 | 11 | 1 | 1 | 0 |
| Jadarian Price (SEA) | 2 | 23 | 104 | 4.5 | 25 | 0 | 1 | 1 |
| Chuba Hubbard (CAR) | 2 | 22 | 102 | 4.6 | 12 | 1 | 0 | 0 |
| Jayden Daniels (WSH) | 2 | 12 | 100 | 8.3 | 20 | 0 | 0 | 0 |