San Francisco 49ers at Indianapolis Colts (December 22, 2025)

Game Recap

Week 16 of the 2025 season saw the San Francisco 49ers defeat the Indianapolis Colts 48-27.

Notes

• Score: San Francisco 49ersSFO defeat Indianapolis ColtsIND 48-27
• Date: Monday, December 22, 2025
• Game Time Kickoff: 8:15PM
• San Francisco 49ers Stats - Yards: 440, Turnovers: 1
• Indianapolis Colts Stats - Yards: 312, Turnovers: 2
• Game Odds:
• -- Line Point Spread: SFO by 5.5
• -- Over/Under: 45.5

Box Score

	1st	2nd	3rd	4th	TOT
SFO	14	10	10	14	48
IND	7	10	3	7	27

Passing Leaders

PLAYER		C-A	YDS	TD	INT	LNG
Brock Purdy	SFO	25-34	295	5	1	26
Philip Rivers	IND	23-35	277	2	1	33
Riley Leonard	IND	0-1	0	0	0	0

Rushing Leaders

PLAYER		ATT	YDS	TD	LNG
Christian McCaffrey	SFO	21	117	0	24
Jonathan Taylor	IND	16	46	1	7
Brian Robinson Jr.	SFO	5	20	0	11
Brock Purdy	SFO	2	11	0	9
Tyler Goodson	IND	3	9	0	6
Josh Downs	IND	1	3	0	3
Mac Jones	SFO	3	-3	0	-1

Receiving Leaders

PLAYER		REC	YDS	TD	LNG
George Kittle	SFO	7	115	1	26
Alec Pierce	IND	4	86	2	33
Jauan Jennings	SFO	5	71	1	21
Josh Downs	IND	5	65	0	18
Jonathan Taylor	IND	3	33	0	19
Michael Pittman Jr.	IND	4	32	0	14
Tyler Warren	IND	3	30	0	19
Christian McCaffrey	SFO	6	29	2	10

Team Total Rushing

TM	ATT	YDS	TD
IND	20	58	1
SFO	31	145	0

Team Total Passing

TM	C-A	YDS	TD	INT	SCK
IND	23-36	277	2	1	2
SFO	25-34	295	5	1	1

More Game Information On The San Francisco 49ers at Indianapolis Colts

• Attendance: 71,160
• Weather:
• Time of Game: 2:56 - 2 hours, 56 minutes