| PLAYER | # |
|---|---|
| Peyton Manning (DEN) | 450 |
| Drew Brees (NO) | 446 |
| Matt Ryan (ATL) | 439 |
| Tom Brady (NE) | 380 |
| Philip Rivers (LAC) | 378 |
| Ben Roethlisberger (PIT) | 375 |
| Matthew Stafford (DET) | 371 |
| Andy Dalton (CIN) | 363 |
| Carson Palmer (ARI) | 362 |
| Joe Flacco (BAL) | 362 |
| Ryan Tannehill (MIA) | 355 |
| Andrew Luck (IND) | 343 |
| Tony Romo (DAL) | 342 |
| Eli Manning (NYG) | 317 |
| Alex Smith (KC) | 308 |
| Chad Henne (JAX) | 305 |
| Cam Newton (CAR) | 292 |
| Robert Griffin (WAS) | 274 |
| Russell Wilson (SEA) | 257 |
| Geno Smith (NYJ) | 247 |
Note: Regular season only.