| PLAYER | # |
|---|---|
| Jonathan Taylor (IND) | 1,811 |
| Nick Chubb (CLE) | 1,259 |
| Joe Mixon (CIN) | 1,205 |
| Najee Harris (PIT) | 1,200 |
| Dalvin Cook (MIN) | 1,159 |
| Antonio Gibson (WAS) | 1,037 |
| Ezekiel Elliott (DAL) | 1,002 |
| Elijah Mitchell (SF) | 963 |
| Derrick Henry (TEN) | 937 |
| Damien Harris (NE) | 929 |
| Melvin Gordon (DEN) | 918 |
| Austin Ekeler (LAC) | 911 |
| Javonte Williams (DEN) | 903 |
| Alvin Kamara (NO) | 898 |
| Josh Jacobs (LV) | 872 |
| Devin Singletary (BUF) | 870 |
| David Montgomery (CHI) | 849 |
| Sony Michel (LAR) | 845 |
| Leonard Fournette (TB) | 812 |
| AJ Dillon (GB) | 803 |
Note: Regular season only.