| PLAYER | # |
|---|---|
| Derrick Henry (TEN) | 2,027 |
| Dalvin Cook (MIN) | 1,557 |
| Jonathan Taylor (IND) | 1,169 |
| Aaron Jones (GB) | 1,104 |
| James Robinson (JAX) | 1,070 |
| David Montgomery (CHI) | 1,070 |
| Nick Chubb (CLE) | 1,067 |
| Josh Jacobs (LV) | 1,065 |
| Lamar Jackson (BAL) | 1,005 |
| Melvin Gordon (DEN) | 986 |
| Ezekiel Elliott (DAL) | 979 |
| Ronald Jones II (TB) | 978 |
| Kenyan Drake (ARI) | 955 |
| Alvin Kamara (NO) | 932 |
| Miles Sanders (PHI) | 867 |
| Kareem Hunt (CLE) | 841 |
| Kyler Murray (ARI) | 819 |
| J.K. Dobbins (BAL) | 805 |
| Clyde Edwards-Helaire (KC) | 803 |
| Antonio Gibson (WAS) | 795 |
Note: Regular season only.