| PLAYER | # |
|---|---|
| Kareem Hunt (KC) | 1,327 |
| Todd Gurley (LAR) | 1,305 |
| Le'Veon Bell (PIT) | 1,291 |
| LeSean McCoy (BUF) | 1,138 |
| Mark Ingram (NO) | 1,124 |
| Jordan Howard (CHI) | 1,122 |
| Melvin Gordon (LAC) | 1,105 |
| Leonard Fournette (JAX) | 1,040 |
| C.J. Anderson (DEN) | 1,007 |
| Ezekiel Elliott (DAL) | 983 |
| Alex Collins (BAL) | 973 |
| Frank Gore (IND) | 961 |
| Carlos Hyde (SF) | 938 |
| Dion Lewis (NE) | 896 |
| Marshawn Lynch (LV) | 891 |
| Lamar Miller (HOU) | 888 |
| Jay Ajayi (MIA) | 873 |
| Devonta Freeman (ATL) | 865 |
| Isaiah Crowell (CLE) | 853 |
| Latavius Murray (MIN) | 842 |
Note: Regular season only.