| PLAYER | # |
|---|---|
| Ezekiel Elliott (DAL) | 1,631 |
| Jordan Howard (CHI) | 1,313 |
| DeMarco Murray (TEN) | 1,287 |
| Jay Ajayi (MIA) | 1,272 |
| Le'Veon Bell (PIT) | 1,268 |
| LeSean McCoy (BUF) | 1,267 |
| David Johnson (ARI) | 1,239 |
| LeGarrette Blount (NE) | 1,161 |
| Devonta Freeman (ATL) | 1,079 |
| Lamar Miller (HOU) | 1,073 |
| Mark Ingram (NO) | 1,043 |
| Frank Gore (IND) | 1,025 |
| Melvin Gordon (LAC) | 997 |
| Carlos Hyde (SF) | 988 |
| Isaiah Crowell (CLE) | 952 |
| Spencer Ware (KC) | 921 |
| Todd Gurley (LAR) | 885 |
| Jeremy Hill (CIN) | 839 |
| Jonathan Stewart (CAR) | 824 |
| Matt Forte (NYJ) | 813 |
Note: Regular season only.