| PLAYER | # |
|---|---|
| Adrian Peterson (MIN) | 1,485 |
| Doug Martin (TB) | 1,402 |
| Todd Gurley (LAR) | 1,106 |
| Darren McFadden (DAL) | 1,089 |
| Chris Ivory (NYJ) | 1,070 |
| Latavius Murray (LV) | 1,066 |
| Devonta Freeman (ATL) | 1,056 |
| Jonathan Stewart (CAR) | 989 |
| Frank Gore (IND) | 967 |
| DeAngelo Williams (PIT) | 907 |
| Matt Forte (CHI) | 898 |
| LeSean McCoy (BUF) | 895 |
| Lamar Miller (MIA) | 872 |
| Rashad Jennings (NYG) | 863 |
| Ronnie Hillman (DEN) | 863 |
| Thomas Rawls (SEA) | 830 |
| Chris Johnson (ARI) | 814 |
| Jeremy Hill (CIN) | 794 |
| Mark Ingram (NO) | 769 |
| Eddie Lacy (GB) | 758 |
Note: Regular season only.