| PLAYER | # |
|---|---|
| Chris Johnson (TEN) | 2,006 |
| Adrian Peterson (MIN) | 1,434 |
| Steven Jackson (LAR) | 1,416 |
| Thomas Jones (NYJ) | 1,402 |
| Maurice Jones-Drew (JAX) | 1,391 |
| Ray Rice (BAL) | 1,339 |
| Ryan Grant (GB) | 1,253 |
| Cedric Benson (CIN) | 1,251 |
| Jonathan Stewart (CAR) | 1,133 |
| Ricky Williams (MIA) | 1,121 |
| Jamaal Charles (KC) | 1,120 |
| Frank Gore (SF) | 1,120 |
| DeAngelo Williams (CAR) | 1,117 |
| Rashard Mendenhall (PIT) | 1,108 |
| Fred Jackson (BUF) | 1,062 |
| Knowshon Moreno (DEN) | 947 |
| Marion Barber (DAL) | 932 |
| Matt Forte (CHI) | 929 |
| Michael Turner (ATL) | 871 |
| Jerome Harrison (CLE) | 862 |
Note: Regular season only.