| PLAYER | # |
|---|---|
| Adrian Peterson (MIN) | 1,860 |
| Michael Turner (ATL) | 1,699 |
| DeAngelo Williams (CAR) | 1,515 |
| Clinton Portis (WAS) | 1,487 |
| Thomas Jones (NYJ) | 1,312 |
| Steve Slaton (HOU) | 1,282 |
| Matt Forte (CHI) | 1,238 |
| Chris Johnson (TEN) | 1,228 |
| Ryan Grant (GB) | 1,203 |
| LaDainian Tomlinson (LAC) | 1,110 |
| Brandon Jacobs (NYG) | 1,089 |
| Steven Jackson (LAR) | 1,042 |
| Marshawn Lynch (BUF) | 1,036 |
| Frank Gore (SF) | 1,036 |
| Derrick Ward (NYG) | 1,025 |
| Jamal Lewis (CLE) | 1,002 |
| Kevin Smith (DET) | 976 |
| Brian Westbrook (PHI) | 936 |
| Ronnie Brown (MIA) | 916 |
| Le'Ron McClain (BAL) | 902 |
Note: Regular season only.