| PLAYER | # |
|---|---|
| Adrian Peterson (MIN) | 1,851 |
| LaDainian Tomlinson (LAC) | 1,474 |
| Brian Westbrook (PHI) | 1,333 |
| Willie Parker (PIT) | 1,316 |
| Jamal Lewis (CLE) | 1,304 |
| Clinton Portis (WAS) | 1,262 |
| Edgerrin James (ARI) | 1,222 |
| Willis McGahee (BAL) | 1,207 |
| Fred Taylor (JAX) | 1,202 |
| Thomas Jones (NYJ) | 1,119 |
| Marshawn Lynch (BUF) | 1,115 |
| LenDale White (TEN) | 1,110 |
| Frank Gore (SF) | 1,102 |
| Joseph Addai (IND) | 1,072 |
| Brandon Jacobs (NYG) | 1,009 |
| Justin Fargas (LV) | 1,009 |
| Steven Jackson (LAR) | 1,002 |
| Marion Barber (DAL) | 975 |
| Ryan Grant (GB) | 956 |
| Earnest Graham (TB) | 898 |
Note: Regular season only.