| PLAYER | # |
|---|---|
| Shaun Alexander (SEA) | 1,880 |
| Tiki Barber (NYG) | 1,860 |
| Larry Johnson (KC) | 1,750 |
| Clinton Portis (WAS) | 1,516 |
| Edgerrin James (IND) | 1,506 |
| LaDainian Tomlinson (LAC) | 1,462 |
| Rudi Johnson (CIN) | 1,458 |
| Warrick Dunn (ATL) | 1,416 |
| Thomas Jones (CHI) | 1,335 |
| Willis McGahee (BUF) | 1,247 |
| Reuben Droughns (CLE) | 1,232 |
| Willie Parker (PIT) | 1,202 |
| Cadillac Williams (TB) | 1,178 |
| Steven Jackson (LAR) | 1,046 |
| LaMont Jordan (LV) | 1,025 |
| Mike Anderson (DEN) | 1,014 |
| Julius Jones (DAL) | 993 |
| Domanick Williams (HOU) | 976 |
| Tatum Bell (DEN) | 921 |
| Ronnie Brown (MIA) | 907 |
Note: Regular season only.