| PLAYER | # |
|---|---|
| Curtis Martin (NYJ) | 1,697 |
| Shaun Alexander (SEA) | 1,696 |
| Corey Dillon (NE) | 1,635 |
| Edgerrin James (IND) | 1,548 |
| Tiki Barber (NYG) | 1,518 |
| Rudi Johnson (CIN) | 1,454 |
| LaDainian Tomlinson (LAC) | 1,335 |
| Clinton Portis (WAS) | 1,315 |
| Reuben Droughns (DEN) | 1,240 |
| Fred Taylor (JAX) | 1,224 |
| Domanick Williams (HOU) | 1,188 |
| Ahman Green (GB) | 1,163 |
| Kevin Jones (DET) | 1,133 |
| Willis McGahee (BUF) | 1,128 |
| Warrick Dunn (ATL) | 1,106 |
| Deuce McAllister (NO) | 1,074 |
| Chris Brown (TEN) | 1,067 |
| Jamal Lewis (BAL) | 1,006 |
| Thomas Jones (CHI) | 948 |
| Jerome Bettis (PIT) | 941 |
Note: Regular season only.