| PLAYER | # |
|---|---|
| Jonathan Taylor (IND) | 18 |
| Damien Harris (NE) | 15 |
| James Conner (ARI) | 15 |
| Joe Mixon (CIN) | 13 |
| Austin Ekeler (LAC) | 12 |
| Derrick Henry (TEN) | 10 |
| Jalen Hurts (PHI) | 10 |
| Ezekiel Elliott (DAL) | 10 |
| Josh Jacobs (LV) | 9 |
| James Robinson (JAX) | 8 |
| Deebo Samuel (SF) | 8 |
| Leonard Fournette (TB) | 8 |
| Nick Chubb (CLE) | 8 |
| Melvin Gordon (DEN) | 8 |
| David Montgomery (CHI) | 7 |
| Ryan Tannehill (TEN) | 7 |
| Devin Singletary (BUF) | 7 |
| Boston Scott (PHI) | 7 |
| Antonio Gibson (WAS) | 7 |
| Najee Harris (PIT) | 7 |
Note: Regular season only.