| PLAYER | # |
|---|---|
| Jonathan Taylor (IND) | 323 |
| Christian McCaffrey (SF) | 311 |
| James Cook (BUF) | 309 |
| Derrick Henry (BAL) | 307 |
| Bijan Robinson (ATL) | 287 |
| Saquon Barkley (PHI) | 280 |
| Ashton Jeanty (LV) | 266 |
| Travis Etienne (JAX) | 260 |
| Kyren Williams (LAR) | 259 |
| Javonte Williams (DAL) | 252 |
| Breece Hall (NYJ) | 243 |
| Jahmyr Gibbs (DET) | 243 |
| Tony Pollard (TEN) | 242 |
| De'Von Achane (MIA) | 238 |
| Rico Dowdle (CAR) | 236 |
| Josh Jacobs (GB) | 234 |
| Chase Brown (CIN) | 232 |
| Quinshon Judkins (CLE) | 230 |
| D'Andre Swift (CHI) | 223 |
| Kenneth Walker III (SEA) | 221 |
Note: Regular season only.