| PLAYER | # |
|---|---|
| Derrick Henry (TEN) | 349 |
| Josh Jacobs (LV) | 340 |
| Nick Chubb (CLE) | 302 |
| Saquon Barkley (NYG) | 295 |
| Najee Harris (PIT) | 272 |
| Dalvin Cook (MIN) | 264 |
| Jamaal Williams (DET) | 262 |
| Miles Sanders (PHI) | 259 |
| Christian McCaffrey (SF) | 244 |
| Ezekiel Elliott (DAL) | 231 |
| Kenneth Walker III (SEA) | 228 |
| Alvin Kamara (NO) | 223 |
| Dameon Pierce (HOU) | 220 |
| Travis Etienne (JAX) | 220 |
| Aaron Jones (GB) | 213 |
| Tyler Allgeier (ATL) | 210 |
| Joe Mixon (CIN) | 210 |
| Rhamondre Stevenson (NE) | 210 |
| Brian Robinson Jr. (WAS) | 205 |
| Austin Ekeler (LAC) | 204 |
Note: Regular season only.