| PLAYER | # |
|---|---|
| Jonathan Taylor (IND) | 332 |
| Najee Harris (PIT) | 307 |
| Joe Mixon (CIN) | 292 |
| Antonio Gibson (WAS) | 258 |
| Dalvin Cook (MIN) | 249 |
| Alvin Kamara (NO) | 240 |
| Ezekiel Elliott (DAL) | 237 |
| Nick Chubb (CLE) | 228 |
| David Montgomery (CHI) | 225 |
| Derrick Henry (TEN) | 219 |
| Josh Jacobs (LV) | 217 |
| Sony Michel (LAR) | 208 |
| Elijah Mitchell (SF) | 207 |
| Austin Ekeler (LAC) | 206 |
| Melvin Gordon (DEN) | 203 |
| Javonte Williams (DEN) | 203 |
| Damien Harris (NE) | 202 |
| James Conner (ARI) | 202 |
| Devin Singletary (BUF) | 188 |
| AJ Dillon (GB) | 187 |
Note: Regular season only.