| PLAYER | # |
|---|---|
| Michael Turner (ATL) | 334 |
| Steven Jackson (LAR) | 330 |
| Arian Foster (HOU) | 327 |
| Rashard Mendenhall (PIT) | 324 |
| Cedric Benson (CIN) | 321 |
| Chris Johnson (TEN) | 316 |
| Ray Rice (BAL) | 307 |
| Maurice Jones-Drew (JAX) | 299 |
| Adrian Peterson (MIN) | 283 |
| Ahmad Bradshaw (NYG) | 276 |
| Peyton Hillis (CLE) | 270 |
| Thomas Jones (KC) | 245 |
| Matt Forte (CHI) | 237 |
| Jamaal Charles (KC) | 230 |
| BenJarvus Green-Ellis (NE) | 229 |
| Darren McFadden (LV) | 223 |
| Fred Jackson (BUF) | 222 |
| LaDainian Tomlinson (NYJ) | 219 |
| LeSean McCoy (PHI) | 207 |
| Frank Gore (SF) | 203 |
Note: Regular season only.