| PLAYER | # |
|---|---|
| Chris Johnson (TEN) | 358 |
| Thomas Jones (NYJ) | 331 |
| Steven Jackson (LAR) | 324 |
| Adrian Peterson (MIN) | 321 |
| Maurice Jones-Drew (JAX) | 312 |
| Cedric Benson (CIN) | 301 |
| Ryan Grant (GB) | 282 |
| Matt Forte (CHI) | 258 |
| Ray Rice (BAL) | 254 |
| Knowshon Moreno (DEN) | 247 |
| Rashard Mendenhall (PIT) | 242 |
| Ricky Williams (MIA) | 241 |
| Fred Jackson (BUF) | 237 |
| Frank Gore (SF) | 229 |
| Brandon Jacobs (NYG) | 224 |
| LaDainian Tomlinson (LAC) | 223 |
| Jonathan Stewart (CAR) | 221 |
| Joseph Addai (IND) | 219 |
| Kevin Smith (DET) | 217 |
| DeAngelo Williams (CAR) | 216 |
Note: Regular season only.