| PLAYER | # |
|---|---|
| Adrian Peterson (MIN) | 383 |
| Michael Turner (ATL) | 376 |
| Clinton Portis (WAS) | 342 |
| Matt Forte (CHI) | 316 |
| Ryan Grant (GB) | 312 |
| LaDainian Tomlinson (LAC) | 292 |
| Thomas Jones (NYJ) | 290 |
| Jamal Lewis (CLE) | 279 |
| DeAngelo Williams (CAR) | 273 |
| Steve Slaton (HOU) | 268 |
| Steven Jackson (LAR) | 253 |
| Chris Johnson (TEN) | 251 |
| Marshawn Lynch (BUF) | 250 |
| Frank Gore (SF) | 240 |
| Marion Barber (DAL) | 238 |
| Kevin Smith (DET) | 238 |
| Brian Westbrook (PHI) | 233 |
| Le'Ron McClain (BAL) | 232 |
| Brandon Jacobs (NYG) | 219 |
| Justin Fargas (LV) | 218 |
Note: Regular season only.