| PLAYER | # |
|---|---|
| Adrian Peterson (MIN) | 389 |
| Clinton Portis (WAS) | 325 |
| Edgerrin James (ARI) | 324 |
| Willie Parker (PIT) | 321 |
| LaDainian Tomlinson (LAC) | 315 |
| Thomas Jones (NYJ) | 310 |
| LenDale White (TEN) | 303 |
| Jamal Lewis (CLE) | 298 |
| Willis McGahee (BAL) | 294 |
| Marshawn Lynch (BUF) | 280 |
| Brian Westbrook (PHI) | 278 |
| Joseph Addai (IND) | 261 |
| Frank Gore (SF) | 260 |
| DeShaun Foster (CAR) | 247 |
| Steven Jackson (LAR) | 237 |
| Warrick Dunn (ATL) | 227 |
| Fred Taylor (JAX) | 223 |
| Earnest Graham (TB) | 222 |
| Justin Fargas (LV) | 222 |
| Shaun Alexander (SEA) | 207 |
Note: Regular season only.