| PLAYER | # |
|---|---|
| Larry Johnson (KC) | 416 |
| LaDainian Tomlinson (LAC) | 348 |
| Steven Jackson (LAR) | 346 |
| Rudi Johnson (CIN) | 341 |
| Willie Parker (PIT) | 337 |
| Edgerrin James (ARI) | 337 |
| Tiki Barber (NYG) | 327 |
| Jamal Lewis (BAL) | 314 |
| Frank Gore (SF) | 312 |
| Chester Taylor (MIN) | 303 |
| Thomas Jones (CHI) | 296 |
| Warrick Dunn (ATL) | 286 |
| Travis Henry (TEN) | 270 |
| Julius Jones (DAL) | 267 |
| Ahman Green (GB) | 266 |
| Willis McGahee (BUF) | 259 |
| Shaun Alexander (SEA) | 252 |
| Ladell Betts (WAS) | 245 |
| Deuce McAllister (NO) | 244 |
| Ronnie Brown (MIA) | 241 |
Note: Regular season only.