| PLAYER | # |
|---|---|
| Shaun Alexander (SEA) | 370 |
| Edgerrin James (IND) | 360 |
| Tiki Barber (NYG) | 357 |
| Clinton Portis (WAS) | 352 |
| LaDainian Tomlinson (LAC) | 339 |
| Rudi Johnson (CIN) | 337 |
| Larry Johnson (KC) | 336 |
| Willis McGahee (BUF) | 325 |
| Thomas Jones (CHI) | 314 |
| Reuben Droughns (CLE) | 309 |
| Cadillac Williams (TB) | 290 |
| Warrick Dunn (ATL) | 280 |
| LaMont Jordan (LV) | 272 |
| Jamal Lewis (BAL) | 269 |
| Julius Jones (DAL) | 257 |
| Willie Parker (PIT) | 255 |
| Steven Jackson (LAR) | 254 |
| Mike Anderson (DEN) | 239 |
| Domanick Williams (HOU) | 230 |
| Chris Brown (TEN) | 224 |
Note: Regular season only.