| PLAYER | # |
|---|---|
| Christian Okoye (KC) | 370 |
| Dalton Hilliard (NO) | 344 |
| Ottis Anderson (NYG) | 325 |
| Eric Dickerson (IND) | 314 |
| Thurman Thomas (BUF) | 298 |
| Bobby Humphrey (DEN) | 294 |
| Barry Sanders (DET) | 280 |
| Neal Anderson (CHI) | 274 |
| Greg Bell (LAR) | 272 |
| Roger Craig (SF) | 271 |
| Herschel Walker (DAL) | 250 |
| John Stephens (NE) | 244 |
| James Brooks (CIN) | 221 |
| Brent Fullwood (GB) | 204 |
| Gerald Riggs (WAS) | 201 |
| Sammie Smith (MIA) | 200 |
| Tim Worley (PIT) | 195 |
| Curt Warner (SEA) | 194 |
| Eric Metcalf (CLE) | 187 |
| Merril Hoge (PIT) | 186 |
Note: Regular season only.