| PLAYER | # |
|---|---|
| Peyton Manning (IND) | 450 |
| Drew Brees (NO) | 448 |
| Matt Schaub (HOU) | 365 |
| Carson Palmer (CIN) | 362 |
| Philip Rivers (LAC) | 357 |
| Matt Ryan (ATL) | 357 |
| Sam Bradford (LAR) | 354 |
| Eli Manning (NYG) | 339 |
| Tom Brady (NE) | 324 |
| Aaron Rodgers (GB) | 312 |
| Joe Flacco (BAL) | 306 |
| Chad Henne (MIA) | 301 |
| Kyle Orton (DEN) | 293 |
| Josh Freeman (TB) | 291 |
| Mark Sanchez (NYJ) | 278 |
| Donovan McNabb (WAS) | 275 |
| Matt Hasselbeck (SEA) | 266 |
| Matt Cassel (KC) | 262 |
| Jay Cutler (CHI) | 261 |
| Shaun Hill (DET) | 257 |
Note: Regular season only.