| PLAYER | # |
|---|---|
| Drew Brees (NO) | 635 |
| Jay Cutler (DEN) | 616 |
| Kurt Warner (ARI) | 598 |
| Donovan McNabb (PHI) | 571 |
| Peyton Manning (IND) | 555 |
| Aaron Rodgers (GB) | 536 |
| David Garrard (JAX) | 535 |
| Brett Favre (NYJ) | 522 |
| Matt Cassel (NE) | 516 |
| Jason Campbell (WAS) | 506 |
| Eli Manning (NYG) | 479 |
| Philip Rivers (LAC) | 478 |
| Chad Pennington (MIA) | 476 |
| Ben Roethlisberger (PIT) | 469 |
| Kyle Orton (CHI) | 465 |
| Tony Romo (DAL) | 450 |
| Marc Bulger (LAR) | 440 |
| Matt Ryan (ATL) | 434 |
| Joe Flacco (BAL) | 428 |
| Tyler Thigpen (KC) | 420 |
Note: Regular season only.