| PLAYER | # |
|---|---|
| Drew Brees (NO) | 652 |
| Tom Brady (NE) | 578 |
| Carson Palmer (CIN) | 575 |
| Matt Hasselbeck (SEA) | 562 |
| Jon Kitna (DET) | 561 |
| Brett Favre (GB) | 535 |
| Eli Manning (NYG) | 529 |
| Derek Anderson (CLE) | 527 |
| Tony Romo (DAL) | 520 |
| Peyton Manning (IND) | 515 |
| Donovan McNabb (PHI) | 473 |
| Jay Cutler (DEN) | 467 |
| Philip Rivers (LAC) | 460 |
| Kurt Warner (ARI) | 451 |
| Jason Campbell (WAS) | 417 |
| Ben Roethlisberger (PIT) | 404 |
| Vince Young (TEN) | 382 |
| Marc Bulger (LAR) | 378 |
| Joey Harrington (ATL) | 348 |
| Damon Huard (KC) | 332 |
Note: Regular season only.