2021 NFL Draft Round 5
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 2021 | 5 | 145 | JAX | Luke Farrell | TE | Ohio St. |
| 2021 | 5 | 146 | NYJ | Jamien Sherwood | DB | Auburn |
| 2021 | 5 | 147 | HOU | Brevin Jordan | TE | Miami (FL) |
| 2021 | 5 | 148 | ATL | Ta'Quon Graham | DL | Texas |
| 2021 | 5 | 149 | CIN | Evan McPherson | K | Florida |
| 2021 | 5 | 150 | PHI | Kenneth Gainwell | RB | Memphis |
| 2021 | 5 | 151 | CHI | Larry Borom | OL | Missouri |
| 2021 | 5 | 152 | DEN | Caden Sterns | DB | Texas |
| 2021 | 5 | 153 | CLE | Tony Fields II | LB | West Virginia |
| 2021 | 5 | 154 | NYJ | Michael Carter II | SAF | Duke |
| 2021 | 5 | 155 | SFO | Jaylon Moore | OT | Western Michigan |
| 2021 | 5 | 156 | PIT | Isaiahh Loudermilk | DE | Wisconsin |
| 2021 | 5 | 157 | MIN | Ihmir Smith-Marsette | WR | Iowa |
| 2021 | 5 | 158 | CAR | Daviyon Nixon | DT | Iowa |
| 2021 | 5 | 159 | LAC | Brenden Jaimes | OL | Nebraska |
| 2021 | 5 | 160 | BAL | Shaun Wade | CB | Ohio St. |
| 2021 | 5 | 161 | BUF | Tommy Doyle | OL | Miami (OH) |
| 2021 | 5 | 162 | KAN | Noah Gray | TE | Duke |
| 2021 | 5 | 163 | WAS | Darrick Forrest | SAF | Cincinnati |
| 2021 | 5 | 164 | DEN | Jamar Johnson | DB | Indiana |
| 2021 | 5 | 165 | IND | Shawn Davis | DB | Florida |
| 2021 | 5 | 166 | CAR | Keith Taylor | DB | Washington |
| 2021 | 5 | 167 | LAS | Nate Hobbs | CB | Illinois |
| 2021 | 5 | 168 | MIN | Zach Davidson | TE | Central Missouri St. |
| 2021 | 5 | 169 | CLE | Richard LeCounte | DB | Georgia |
| 2021 | 5 | 170 | HOU | Garret Wallow | LB | TCU |
| 2021 | 5 | 171 | BAL | Daelin Hayes | DL | Notre Dame |
| 2021 | 5 | 172 | SFO | Deommodore Lenoir | CB | Oregon |
| 2021 | 5 | 173 | GNB | Tedarrell Slaton | DL | Florida |
| 2021 | 5 | 174 | RAM | Earnest Brown IV | DE | Northwestern |
| 2021 | 5 | 175 | NYJ | Jason Pinnock | CB | Pittsburgh |
| 2021 | 5 | 176 | TAM | K.J. Britt | LB | Auburn |
| 2021 | 5 | 177 | NWE | Cameron McGrone | LB | Michigan |
| 2021 | 5 | 178 | GNB | Shemar Jean-Charles | DB | Appalachian St. |
| 2021 | 5 | 179 | DAL | Simi Fehoko | WR | Stanford |
| 2021 | 5 | 180 | SFO | Talanoa Hufanga | SAF | USC |
| 2021 | 5 | 181 | KAN | Cornell Powell | WR | Clemson |
| 2021 | 5 | 182 | ATL | Adetokunbo Ogundeji | DL | Notre Dame |
| 2021 | 5 | 183 | ATL | Avery Williams | CB | Boise St. |
| 2021 | 5 | 184 | BAL | Ben Mason | FB | Michigan |
