2016 NFL Draft Round 5
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 2016 | 5 | 140 | TEN | Tajae Sharpe | WR | Massachusetts |
| 2016 | 5 | 141 | CAR | Zack Sanchez | CB | Oklahoma |
| 2016 | 5 | 142 | SFO | Ronald Blair | DE | Appalachian St. |
| 2016 | 5 | 143 | LAS | DeAndre Washington | RB | Texas Tech |
| 2016 | 5 | 144 | DEN | Connor McGovern | G | Missouri |
| 2016 | 5 | 145 | SFO | John Theus | T | Georgia |
| 2016 | 5 | 146 | BAL | Matt Judon | DE | Grand Valley St. |
| 2016 | 5 | 147 | SEA | Quinton Jefferson | DT | Maryland |
| 2016 | 5 | 148 | TAM | Caleb Benenoch | T | UCLA |
| 2016 | 5 | 149 | NYG | Paul Perkins | RB | UCLA |
| 2016 | 5 | 150 | CHI | Jordan Howard | RB | Indiana |
| 2016 | 5 | 151 | DET | Joe Dahl | G | Washington St. |
| 2016 | 5 | 152 | WAS | Matthew Ioannidis | DT | Temple |
| 2016 | 5 | 153 | PHI | Wendell Smallwood | RB | West Virginia |
| 2016 | 5 | 154 | CLE | Jordan Payton | WR | UCLA |
| 2016 | 5 | 155 | IND | Joe Haeg | T | North Dakota St. |
| 2016 | 5 | 156 | BUF | Jonathan Williams | RB | Arkansas |
| 2016 | 5 | 157 | TEN | LeShaun Sims | CB | Southern Utah |
| 2016 | 5 | 158 | NYJ | Brandon Shell | T | South Carolina |
| 2016 | 5 | 159 | HOU | K.J. Dillon | S | West Virginia |
| 2016 | 5 | 160 | MIN | Kentrell Brothers | OLB | Missouri |
| 2016 | 5 | 161 | CIN | Christian Westerman | G | Arizona St. |
| 2016 | 5 | 162 | KAN | Kevin Hogan | QB | Stanford |
| 2016 | 5 | 163 | GNB | Trevor Davis | WR | California |
| 2016 | 5 | 164 | PHI | Halapoulivaati Vaitai | T | TCU |
| 2016 | 5 | 165 | KAN | Tyreek Hill | WR | West Alabama |
| 2016 | 5 | 166 | HOU | D.J. Reader | NT | Clemson |
| 2016 | 5 | 167 | ARI | Marqui Christian | S | Midwestern St. |
| 2016 | 5 | 168 | CLE | Spencer Drango | G | Baylor |
| 2016 | 5 | 169 | DET | Antwione Williams | LB | Georgia Southern |
| 2016 | 5 | 170 | ARI | Cole Toner | T | Harvard |
| 2016 | 5 | 171 | SEA | Alex Collins | RB | Arkansas |
| 2016 | 5 | 172 | CLE | Rashard Higgins | WR | Colorado St. |
| 2016 | 5 | 173 | CLE | Trey Caldwell | DB | La-Monroe |
| 2016 | 5 | 174 | SFO | Fahn Cooper | T | Mississippi |
| 2016 | 5 | 175 | LAC | Jatavis Brown | OLB | Akron |
