2010 NFL Draft Round 1
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 2010 | 1 | 1 | RAM | Sam Bradford | QB | Oklahoma |
| 2010 | 1 | 2 | DET | Ndamukong Suh | DT | Nebraska |
| 2010 | 1 | 3 | TAM | Gerald McCoy | DT | Oklahoma |
| 2010 | 1 | 4 | WAS | Trent Williams | T | Oklahoma |
| 2010 | 1 | 5 | KAN | Eric Berry | DB | Tennessee |
| 2010 | 1 | 6 | SEA | Russell Okung | T | Oklahoma St. |
| 2010 | 1 | 7 | CLE | Joe Haden | DB | Florida |
| 2010 | 1 | 8 | LAS | Rolando McClain | LB | Alabama |
| 2010 | 1 | 9 | BUF | C.J. Spiller | RB | Clemson |
| 2010 | 1 | 10 | JAX | Tyson Alualu | DT | California |
| 2010 | 1 | 11 | SFO | Anthony Davis | T | Rutgers |
| 2010 | 1 | 12 | LAC | Ryan Mathews | RB | Fresno St. |
| 2010 | 1 | 13 | PHI | Brandon Graham | DE | Michigan |
| 2010 | 1 | 14 | SEA | Earl Thomas | DB | Texas |
| 2010 | 1 | 15 | NYG | Jason Pierre-Paul | DE | South Florida |
| 2010 | 1 | 16 | TEN | Derrick Morgan | DE | Georgia Tech |
| 2010 | 1 | 17 | SFO | Mike Iupati | G | Idaho |
| 2010 | 1 | 18 | PIT | Maurkice Pouncey | C | Florida |
| 2010 | 1 | 19 | ATL | Sean Weatherspoon | LB | Missouri |
| 2010 | 1 | 20 | HOU | Kareem Jackson | DB | Alabama |
| 2010 | 1 | 21 | CIN | Jermaine Gresham | TE | Oklahoma |
| 2010 | 1 | 22 | DEN | Demaryius Thomas | WR | Georgia Tech |
| 2010 | 1 | 23 | GNB | Bryan Bulaga | T | Iowa |
| 2010 | 1 | 24 | DAL | Dez Bryant | WR | Oklahoma St. |
| 2010 | 1 | 25 | DEN | Tim Tebow | QB | Florida |
| 2010 | 1 | 26 | ARI | Dan Williams | DT | Tennessee |
| 2010 | 1 | 27 | NWE | Devin McCourty | DB | Rutgers |
| 2010 | 1 | 28 | MIA | Jared Odrick | DE | Penn St. |
| 2010 | 1 | 29 | NYJ | Kyle Wilson | DB | Boise St. |
| 2010 | 1 | 30 | DET | Jahvid Best | RB | California |
| 2010 | 1 | 31 | IND | Jerry Hughes | DE | TCU |
| 2010 | 1 | 32 | NOR | Patrick Robinson | DB | Florida St. |
