1980 NFL Draft Round 1
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 1980 | 1 | 1 | DET | Billy Sims | RB | Oklahoma |
| 1980 | 1 | 2 | NYJ | Lam Jones | WR | Texas |
| 1980 | 1 | 3 | CIN | Anthony Munoz | T | USC |
| 1980 | 1 | 4 | GNB | Bruce Clark | DE | Penn St. |
| 1980 | 1 | 5 | IND | Curtis Dickey | RB | Texas A&M |
| 1980 | 1 | 6 | ARI | Curtis Greer | DE | Michigan |
| 1980 | 1 | 7 | ATL | Junior Miller | TE | Nebraska |
| 1980 | 1 | 8 | NYG | Mark Haynes | DB | Colorado |
| 1980 | 1 | 9 | MIN | Doug Martin | DE | Washington |
| 1980 | 1 | 10 | SEA | Jacob Green | DE | Texas A&M |
| 1980 | 1 | 11 | KAN | Brad Budde | G | USC |
| 1980 | 1 | 12 | NOR | Stan Brock | T | Colorado |
| 1980 | 1 | 13 | SFO | Earl Cooper | RB | Rice |
| 1980 | 1 | 14 | NWE | Roland James | DB | Tennessee |
| 1980 | 1 | 15 | LAS | Marc Wilson | QB | BYU |
| 1980 | 1 | 16 | BUF | Jim Ritcher | G | North Carolina St. |
| 1980 | 1 | 17 | RAM | Johnnie Johnson | DB | Texas |
| 1980 | 1 | 18 | WAS | Art Monk | WR | Syracuse |
| 1980 | 1 | 19 | CHI | Otis Wilson | LB | Louisville |
| 1980 | 1 | 20 | SFO | Jim Stuckey | DE | Clemson |
| 1980 | 1 | 21 | MIA | Don McNeal | DB | Alabama |
| 1980 | 1 | 22 | TAM | Ray Snell | G | Wisconsin |
| 1980 | 1 | 23 | PHI | Roynell Young | DB | Alcorn St. |
| 1980 | 1 | 24 | IND | Derrick Hatchett | DB | Texas |
| 1980 | 1 | 25 | NWE | Vagas Ferguson | RB | Notre Dame |
| 1980 | 1 | 26 | GNB | George Cumby | LB | Oklahoma |
| 1980 | 1 | 27 | CLE | Charles White | RB | USC |
| 1980 | 1 | 28 | PIT | Mark Malone | QB | Arizona St. |
