| PLAYER | # |
|---|---|
| James Cook (BUF) | 1,621 |
| Derrick Henry (BAL) | 1,595 |
| Jonathan Taylor (IND) | 1,585 |
| Bijan Robinson (ATL) | 1,478 |
| De'Von Achane (MIA) | 1,350 |
| Kyren Williams (LAR) | 1,252 |
| Jahmyr Gibbs (DET) | 1,223 |
| Christian McCaffrey (SF) | 1,202 |
| Javonte Williams (DAL) | 1,201 |
| Saquon Barkley (PHI) | 1,140 |
| Travis Etienne (JAX) | 1,107 |
| D'Andre Swift (CHI) | 1,087 |
| Tony Pollard (TEN) | 1,082 |
| Rico Dowdle (CAR) | 1,076 |
| Breece Hall (NYJ) | 1,065 |
| Kenneth Walker III (SEA) | 1,027 |
| Chase Brown (CIN) | 1,019 |
| Ashton Jeanty (LV) | 975 |
| Jaylen Warren (PIT) | 958 |
| Josh Jacobs (GB) | 929 |
Note: Regular season only.