| PLAYER | # |
|---|---|
| Christian McCaffrey (SF) | 1,459 |
| Derrick Henry (TEN) | 1,167 |
| Kyren Williams (LAR) | 1,144 |
| James Cook (BUF) | 1,122 |
| D'Andre Swift (PHI) | 1,049 |
| James Conner (ARI) | 1,040 |
| Najee Harris (PIT) | 1,035 |
| Joe Mixon (CIN) | 1,034 |
| David Montgomery (DET) | 1,015 |
| Raheem Mostert (MIA) | 1,012 |
| Travis Etienne (JAX) | 1,008 |
| Tony Pollard (DAL) | 1,005 |
| Breece Hall (NYJ) | 994 |
| Rachaad White (TB) | 990 |
| Bijan Robinson (ATL) | 976 |
| Saquon Barkley (NYG) | 962 |
| Jahmyr Gibbs (DET) | 945 |
| Isiah Pacheco (KC) | 935 |
| Kenneth Walker III (SEA) | 905 |
| Chuba Hubbard (CAR) | 902 |
Note: Regular season only.