| PLAYER | # |
|---|---|
| Jamal Lewis (BAL) | 2,066 |
| Ahman Green (GB) | 1,883 |
| LaDainian Tomlinson (LAC) | 1,645 |
| Deuce McAllister (NO) | 1,641 |
| Clinton Portis (DEN) | 1,591 |
| Fred Taylor (JAX) | 1,572 |
| Ricky Williams (IND) | 1,527 |
| Stephen Davis (CAR) | 1,444 |
| Shaun Alexander (SEA) | 1,435 |
| Priest Holmes (KC) | 1,420 |
| Travis Henry (BUF) | 1,356 |
| Curtis Martin (NYJ) | 1,308 |
| Edgerrin James (IND) | 1,259 |
| Tiki Barber (NYG) | 1,216 |
| Eddie George (TEN) | 1,031 |
| Domanick Williams (HOU) | 1,031 |
| Anthony Thomas (CHI) | 1,024 |
| Kevan Barlow (SF) | 1,024 |
| Troy Hambrick (DAL) | 972 |
| Rudi Johnson (CIN) | 957 |
Note: Regular season only.