| PLAYER | YDs | GP |
|---|---|---|
| Eric Dickerson - 1986 | 5,597 | 50 |
| Earl Campbell - 1981 | 5,489 | 50 |
| Clinton Portis - 2005 | 5,066 | 50 |
| Terrell Davis - 1998 | 5,062 | 50 |
| Walter Payton - 1978 | 5,009 | 50 |
| Larry Johnson - 2009 | 4,947 | 50 |
| Jamal Lewis - 2004 | 4,927 | 50 |
| Ezekiel Elliott - 2019 | 4,881 | 50 |
| Derrick Henry - 2021 | 4,856 | 50 |
| Gerald Riggs - 1987 | 4,824 | 50 |
| Edgerrin James - 2002 | 4,814 | 50 |
| LaDainian Tomlinson - 2004 | 4,772 | 50 |
| Priest Holmes - 2003 | 4,744 | 50 |
| Chris Johnson - 2011 | 4,723 | 50 |
| Maurice Jones-Drew - 2012 | 4,642 | 50 |
Data through Feb 9 games.