2021 NFL Draft Round 6
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 2021 | 6 | 185 | LAC | Nick Niemann | LB | Iowa |
| 2021 | 6 | 186 | NYJ | Hamsah Nasirildeen | DB | Florida St. |
| 2021 | 6 | 187 | ATL | Frank Darby | WR | Arizona St. |
| 2021 | 6 | 188 | NWE | Joshuah Bledsoe | SAF | Missouri |
| 2021 | 6 | 189 | PHI | Marlon Tuipulotu | DL | USC |
| 2021 | 6 | 190 | CIN | Trey Hill | OL | Georgia |
| 2021 | 6 | 191 | PHI | Tarron Jackson | DE | Coastal Carolina |
| 2021 | 6 | 192 | DAL | Quinton Bohanna | DT | Kentucky |
| 2021 | 6 | 193 | CAR | Deonte Brown | OL | Alabama |
| 2021 | 6 | 194 | SFO | Elijah Mitchell | RB | Louisiana |
| 2021 | 6 | 195 | HOU | Roy Lopez | DL | Arizona |
| 2021 | 6 | 196 | NYG | Gary Brightwell | RB | Arizona |
| 2021 | 6 | 197 | NWE | William Sherman | OL | Colorado |
| 2021 | 6 | 198 | LAC | Larry Rountree III | RB | Missouri |
| 2021 | 6 | 199 | MIN | Jaylen Twyman | DL | Pittsburgh |
| 2021 | 6 | 200 | NYJ | Brandin Echols | CB | Kentucky |
| 2021 | 6 | 201 | NYG | Rodarius Williams | CB | Oklahoma St. |
| 2021 | 6 | 202 | CIN | Chris Evans | RB | Michigan |
| 2021 | 6 | 203 | BUF | Marquez Stevenson | WR | Houston |
| 2021 | 6 | 204 | CAR | Shi Smith | WR | South Carolina |
| 2021 | 6 | 205 | TEN | Racey McMath | WR | LSU |
| 2021 | 6 | 206 | NOR | Landon Young | OT | Kentucky |
| 2021 | 6 | 208 | SEA | Stone Forsythe | OL | Florida |
| 2021 | 6 | 209 | JAX | Jalen Camp | WR | Georgia Tech |
| 2021 | 6 | 210 | ARI | Victor Dimukeje | DE | Duke |
| 2021 | 6 | 211 | CLE | Demetric Felton | RB | UCLA |
| 2021 | 6 | 212 | BUF | Damar Hamlin | DB | Pittsburgh |
| 2021 | 6 | 213 | BUF | Rachad Wildgoose Jr. | CB | Wisconsin |
| 2021 | 6 | 214 | GNB | Cole Van Lanen | OL | Wisconsin |
| 2021 | 6 | 215 | TEN | Brady Breeze | SAF | Oregon |
| 2021 | 6 | 216 | PIT | Quincy Roche | DL | Miami (FL) |
| 2021 | 6 | 217 | CHI | Khalil Herbert | RB | Virginia Tech |
| 2021 | 6 | 218 | IND | Sam Ehlinger | QB | Texas |
| 2021 | 6 | 219 | DEN | Seth Williams | WR | Auburn |
| 2021 | 6 | 220 | GNB | Isaiah McDuffie | LB | Boston Col. |
| 2021 | 6 | 221 | CHI | Dazz Newsome | WR | North Carolina |
| 2021 | 6 | 222 | CAR | Thomas Fletcher | LS | Alabama |
| 2021 | 6 | 223 | ARI | Tay Gowan | DB | Central Florida |
| 2021 | 6 | 224 | PHI | JaCoby Stevens | SAF | LSU |
| 2021 | 6 | 225 | WAS | Camaron Cheeseman | LS | Michigan |
| 2021 | 6 | 226 | KAN | Trey Smith | OL | Tennessee |
| 2021 | 6 | 227 | DAL | Israel Mukuamu | DB | South Carolina |
| 2021 | 6 | 228 | CHI | Thomas Graham Jr. | CB | Oregon |
