2000 NFL Draft Round 5
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 2000 | 5 | 130 | CLE | Anthony Malbrough | DB | Texas Tech |
| 2000 | 5 | 131 | NOR | Tutan Reyes | G | Mississippi |
| 2000 | 5 | 132 | SFO | Paul Smith | RB | Texas-El Paso |
| 2000 | 5 | 133 | CIN | Robert Bean | DB | Mississippi St. |
| 2000 | 5 | 134 | ATL | Anthony Midget | DB | Virginia Tech |
| 2000 | 5 | 135 | TEN | Aric Morris | DB | Michigan St. |
| 2000 | 5 | 136 | ARI | Mao Tosi | DT | Idaho |
| 2000 | 5 | 137 | PIT | Clark Haggans | LB | Colorado St. |
| 2000 | 5 | 138 | IND | Matt Johnson | G | BYU |
| 2000 | 5 | 139 | RAM | Brian Young | DT | Texas-El Paso |
| 2000 | 5 | 140 | NYG | Ralph Brown | DB | Nebraska |
| 2000 | 5 | 141 | NWE | Dave Stachelski | TE | Boise St. |
| 2000 | 5 | 142 | LAS | Shane Lechler | P | Texas A&M |
| 2000 | 5 | 143 | NYJ | Windrell Hayes | WR | USC |
| 2000 | 5 | 144 | DAL | Michael Wiley | RB | Ohio St. |
| 2000 | 5 | 145 | DET | Todd Franz | DB | Tulsa |
| 2000 | 5 | 146 | CLE | Lamar Chapman | DB | Kansas St. |
| 2000 | 5 | 147 | CAR | Gillis Wilson | DE | Southern |
| 2000 | 5 | 148 | BAL | Richard Mercier | G | Miami (FL) |
| 2000 | 5 | 149 | GNB | Kabeer Gbaja-Biamila | DE | San Diego St. |
| 2000 | 5 | 150 | SFO | John Milem | DE | Lenoir-Rhyne |
| 2000 | 5 | 151 | GNB | Joey Jamison | WR | Texas Southern |
| 2000 | 5 | 152 | MIA | Arturo Freeman | DB | South Carolina |
| 2000 | 5 | 153 | KAN | Dante Hall | WR | Texas A&M |
| 2000 | 5 | 154 | DEN | Muneer Moore | WR | Richmond |
| 2000 | 5 | 155 | WAS | Quincy Sanders | DB | UNLV |
| 2000 | 5 | 156 | BUF | Sammy Morris | RB | Texas Tech |
| 2000 | 5 | 157 | TAM | James Whalen | TE | Kentucky |
| 2000 | 5 | 158 | NOR | Austin Wheatley | TE | Iowa |
| 2000 | 5 | 159 | JAX | Kiwaukee Thomas | DB | Georgia Southern |
| 2000 | 5 | 160 | TEN | Frank Chamberlin | LB | Boston Col. |
| 2000 | 5 | 161 | NWE | Jeff Marriott | DT | Missouri |
| 2000 | 5 | 162 | KAN | Pat Dennis | DB | La-Monroe |
| 2000 | 5 | 163 | PIT | Tee Martin | QB | Tennessee |
| 2000 | 5 | 164 | ARI | Jay Tant | TE | Northwestern |
| 2000 | 5 | 165 | MIN | Troy Walters | WR | Stanford |
| 2000 | 5 | 166 | NOR | Chad Morton | RB | USC |
