2021 NFL Draft Round 4
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 2021 | 4 | 106 | JAX | Jay Tufele | DL | USC |
| 2021 | 4 | 107 | NYJ | Michael Carter | RB | North Carolina |
| 2021 | 4 | 108 | ATL | Darren Hall | CB | San Diego St. |
| 2021 | 4 | 109 | TEN | Dez Fitzpatrick | WR | Louisville |
| 2021 | 4 | 110 | CLE | James Hudson | OL | Cincinnati |
| 2021 | 4 | 111 | CIN | Cameron Sample | DE | Tulane |
| 2021 | 4 | 112 | DET | Amon-Ra St. Brown | WR | USC |
| 2021 | 4 | 113 | DET | Derrick Barnes | DE | Purdue |
| 2021 | 4 | 114 | ATL | Drew Dalman | C | Stanford |
| 2021 | 4 | 115 | DAL | Jabril Cox | LB | LSU |
| 2021 | 4 | 116 | NYG | Elerson G. Smith | DL | Northern Iowa |
| 2021 | 4 | 117 | RAM | Bobby Brown III | DL | Texas A&M |
| 2021 | 4 | 118 | LAC | Chris Rumph II | DE | Duke |
| 2021 | 4 | 119 | MIN | Kene Nwangwu | RB | Iowa St. |
| 2021 | 4 | 120 | NWE | Rhamondre Stevenson | RB | Oklahoma |
| 2021 | 4 | 121 | JAX | Jordan Smith | OLB | Ala-Birmingham |
| 2021 | 4 | 122 | CIN | Tyler Shelvin | DT | LSU |
| 2021 | 4 | 123 | PHI | Zech McPhearson | DB | Texas Tech |
| 2021 | 4 | 124 | WAS | John Bates | TE | Boise St. |
| 2021 | 4 | 125 | MIN | Camryn Bynum | CB | California |
| 2021 | 4 | 126 | CAR | Chuba Hubbard | RB | Oklahoma St. |
| 2021 | 4 | 127 | IND | Kylen Granson | TE | SMU |
| 2021 | 4 | 128 | PIT | Dan Moore Jr. | OL | Texas A&M |
| 2021 | 4 | 129 | TAM | Jaelon Darden | WR | North Texas |
| 2021 | 4 | 130 | RAM | Robert Rochell | DB | Central Arkansas |
| 2021 | 4 | 131 | BAL | Tylan Wallace | WR | Oklahoma St. |
| 2021 | 4 | 132 | CLE | Tommy Togiai | DT | Ohio St. |
| 2021 | 4 | 133 | NOR | Ian Book | QB | Notre Dame |
| 2021 | 4 | 134 | MIN | Janarius Robinson | DE | Florida St. |
| 2021 | 4 | 135 | TEN | Rashad Weaver | DL | Pittsburgh |
| 2021 | 4 | 136 | ARI | Marco Wilson | CB | Florida |
| 2021 | 4 | 137 | SEA | Tre Brown | CB | Oklahoma |
| 2021 | 4 | 138 | DAL | Josh Ball | OL | Marshall |
| 2021 | 4 | 139 | CIN | D'Ante Smith | OT | East Carolina |
| 2021 | 4 | 140 | PIT | Buddy Johnson | LB | Texas A&M |
| 2021 | 4 | 141 | RAM | Jacob Harris | WR | Central Florida |
| 2021 | 4 | 142 | GNB | Royce Newman | G | Mississippi |
| 2021 | 4 | 143 | LAS | Tyree Gillespie | SAF | Missouri |
| 2021 | 4 | 144 | KAN | Joshua Kaindoh | DE | Florida St. |
