1981 NFL Draft Round 2
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 1981 | 2 | 29 | NOR | Russell Gary | DB | Nebraska |
| 1981 | 2 | 30 | NYJ | Marion Barber Jr. | RB | Minnesota |
| 1981 | 2 | 31 | SEA | David Hughes | RB | Boise St. |
| 1981 | 2 | 32 | NYG | Dave Young | TE | Purdue |
| 1981 | 2 | 33 | ARI | Neil Lomax | QB | Portland St. |
| 1981 | 2 | 34 | TAM | James Wilder | RB | Missouri |
| 1981 | 2 | 35 | GNB | Gary Lewis | TE | Texas-Arlington |
| 1981 | 2 | 36 | SFO | John Harty | NT | Iowa |
| 1981 | 2 | 37 | CIN | Cris Collinsworth | WR | Florida |
| 1981 | 2 | 38 | CHI | Mike Singletary | LB | Baylor |
| 1981 | 2 | 39 | MIN | Mardye McDole | WR | Mississippi St. |
| 1981 | 2 | 40 | SFO | Eric Wright | DB | Missouri |
| 1981 | 2 | 41 | KAN | Joe Delaney | RB | Northwestern St. (LA) |
| 1981 | 2 | 42 | DEN | Clay Brown | TE | BYU |
| 1981 | 2 | 43 | RAM | Jim Collins | LB | Syracuse |
| 1981 | 2 | 44 | PIT | Anthony Washington | DB | Fresno St. |
| 1981 | 2 | 45 | MIN | Robin Sendlein | LB | Texas |
| 1981 | 2 | 46 | DET | Curtis Green | DE | Alabama St. |
| 1981 | 2 | 47 | NWE | Tony Collins | RB | East Carolina |
| 1981 | 2 | 48 | LAS | Howie Long | DE | Villanova |
| 1981 | 2 | 49 | BUF | Chris Williams | DB | LSU |
| 1981 | 2 | 50 | BUF | Byron Franklin | WR | Auburn |
| 1981 | 2 | 51 | NOR | Rickey Jackson | LB | Pittsburgh |
| 1981 | 2 | 52 | MIN | Jarvis Redwine | RB | Nebraska |
| 1981 | 2 | 53 | DAL | Doug Donley | WR | Ohio St. |
| 1981 | 2 | 54 | ATL | Lyman White | LB | LSU |
| 1981 | 2 | 55 | PHI | Dean Miraldi | T | Utah |
| 1981 | 2 | 56 | MIA | Andra Franklin | RB | Nebraska |
