2021 NFL Draft Round 1
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 2021 | 1 | 1 | JAX | Trevor Lawrence | QB | Clemson |
| 2021 | 1 | 2 | NYJ | Zach Wilson | QB | BYU |
| 2021 | 1 | 3 | SFO | Trey Lance | QB | North Dakota St. |
| 2021 | 1 | 4 | ATL | Kyle Pitts | TE | Florida |
| 2021 | 1 | 5 | CIN | Ja'Marr Chase | WR | LSU |
| 2021 | 1 | 6 | MIA | Jaylen Waddle | WR | Alabama |
| 2021 | 1 | 7 | DET | Penei Sewell | OL | Oregon |
| 2021 | 1 | 8 | CAR | Jaycee Horn | DB | South Carolina |
| 2021 | 1 | 9 | DEN | Patrick Surtain II | DB | Alabama |
| 2021 | 1 | 10 | PHI | DeVonta Smith | WR | Alabama |
| 2021 | 1 | 11 | CHI | Justin Fields | QB | Ohio St. |
| 2021 | 1 | 12 | DAL | Micah Parsons | LB | Penn St. |
| 2021 | 1 | 13 | LAC | Rashawn Slater | OL | Northwestern |
| 2021 | 1 | 14 | NYJ | Alijah Vera-Tucker | OL | USC |
| 2021 | 1 | 15 | NWE | Mac Jones | QB | Alabama |
| 2021 | 1 | 16 | ARI | Zaven Collins | LB | Tulsa |
| 2021 | 1 | 17 | LAS | Alex Leatherwood | OL | Alabama |
| 2021 | 1 | 18 | MIA | Jaelan Phillips | DL | Miami (FL) |
| 2021 | 1 | 19 | WAS | Jamin Davis | LB | Kentucky |
| 2021 | 1 | 20 | NYG | Kadarius Toney | WR | Florida |
| 2021 | 1 | 21 | IND | Kwity Paye | DL | Michigan |
| 2021 | 1 | 22 | TEN | Caleb Farley | DB | Virginia Tech |
| 2021 | 1 | 23 | MIN | Christian Darrisaw | OL | Virginia Tech |
| 2021 | 1 | 24 | PIT | Najee Harris | RB | Alabama |
| 2021 | 1 | 25 | JAX | Travis Etienne | RB | Clemson |
| 2021 | 1 | 26 | CLE | Greg Newsome II | DB | Northwestern |
| 2021 | 1 | 27 | BAL | Rashod Bateman | WR | Minnesota |
| 2021 | 1 | 28 | NOR | Payton Turner | DE | Houston |
| 2021 | 1 | 29 | GNB | Eric Stokes | DB | Georgia |
| 2021 | 1 | 30 | BUF | Gregory Rousseau | DL | Miami (FL) |
| 2021 | 1 | 31 | BAL | Jayson Oweh | DE | Penn St. |
| 2021 | 1 | 32 | TAM | Joe Tryon | OLB | Washington |
