2016 NFL Draft Round 1
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 2016 | 1 | 1 | RAM | Jared Goff | QB | California |
| 2016 | 1 | 2 | PHI | Carson Wentz | QB | North Dakota St. |
| 2016 | 1 | 3 | LAC | Joey Bosa | DE | Ohio St. |
| 2016 | 1 | 4 | DAL | Ezekiel Elliott | RB | Ohio St. |
| 2016 | 1 | 5 | JAX | Jalen Ramsey | CB | Florida St. |
| 2016 | 1 | 6 | BAL | Ronnie Stanley | T | Notre Dame |
| 2016 | 1 | 7 | SFO | DeForest Buckner | DE | Oregon |
| 2016 | 1 | 8 | TEN | Jack Conklin | T | Michigan St. |
| 2016 | 1 | 9 | CHI | Leonard Floyd | OLB | Georgia |
| 2016 | 1 | 10 | NYG | Eli Apple | CB | Ohio St. |
| 2016 | 1 | 11 | TAM | Vernon Hargreaves III | CB | Florida |
| 2016 | 1 | 12 | NOR | Sheldon Rankins | DT | Louisville |
| 2016 | 1 | 13 | MIA | Laremy Tunsil | T | Mississippi |
| 2016 | 1 | 14 | LAS | Karl Joseph | S | West Virginia |
| 2016 | 1 | 15 | CLE | Corey Coleman | WR | Baylor |
| 2016 | 1 | 16 | DET | Taylor Decker | T | Ohio St. |
| 2016 | 1 | 17 | ATL | Keanu Neal | S | Florida |
| 2016 | 1 | 18 | IND | Ryan Kelly | C | Alabama |
| 2016 | 1 | 19 | BUF | Shaq Lawson | DE | Clemson |
| 2016 | 1 | 20 | NYJ | Darron Lee | OLB | Ohio St. |
| 2016 | 1 | 21 | HOU | Will Fuller | WR | Notre Dame |
| 2016 | 1 | 22 | WAS | Josh Doctson | WR | TCU |
| 2016 | 1 | 23 | MIN | Laquon Treadwell | WR | Mississippi |
| 2016 | 1 | 24 | CIN | William Jackson III | CB | Houston |
| 2016 | 1 | 25 | PIT | Artie Burns | CB | Miami (FL) |
| 2016 | 1 | 26 | DEN | Paxton Lynch | QB | Memphis |
| 2016 | 1 | 27 | GNB | Kenny Clark | DT | UCLA |
| 2016 | 1 | 28 | SFO | Joshua Garnett | G | Stanford |
| 2016 | 1 | 29 | ARI | Robert Nkemdiche | DT | Mississippi |
| 2016 | 1 | 30 | CAR | Vernon Butler | DT | Louisiana Tech |
| 2016 | 1 | 31 | SEA | Germain Ifedi | G | Texas A&M |
