2006 NFL Draft Round 1
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 2006 | 1 | 1 | HOU | Mario Williams | DE | North Carolina St. |
| 2006 | 1 | 2 | NOR | Reggie Bush | RB | USC |
| 2006 | 1 | 3 | TEN | Vince Young | QB | Texas |
| 2006 | 1 | 4 | NYJ | D'Brickashaw Ferguson | T | Virginia |
| 2006 | 1 | 5 | GNB | A.J. Hawk | LB | Ohio St. |
| 2006 | 1 | 6 | SFO | Vernon Davis | TE | Maryland |
| 2006 | 1 | 7 | LAS | Michael Huff | DB | Texas |
| 2006 | 1 | 8 | BUF | Donte Whitner | DB | Ohio St. |
| 2006 | 1 | 9 | DET | Ernie Sims | LB | Florida St. |
| 2006 | 1 | 10 | ARI | Matt Leinart | QB | USC |
| 2006 | 1 | 11 | DEN | Jay Cutler | QB | Vanderbilt |
| 2006 | 1 | 12 | BAL | Haloti Ngata | DT | Oregon |
| 2006 | 1 | 13 | CLE | Kamerion Wimbley | DE | Florida St. |
| 2006 | 1 | 14 | PHI | Brodrick Bunkley | DT | Florida St. |
| 2006 | 1 | 15 | RAM | Tye Hill | DB | Clemson |
| 2006 | 1 | 16 | MIA | Jason Allen | DB | Tennessee |
| 2006 | 1 | 17 | MIN | Chad Greenway | LB | Iowa |
| 2006 | 1 | 18 | DAL | Bobby Carpenter | LB | Ohio St. |
| 2006 | 1 | 19 | LAC | Antonio Cromartie | DB | Florida St. |
| 2006 | 1 | 20 | KAN | Tamba Hali | DE | Penn St. |
| 2006 | 1 | 21 | NWE | Laurence Maroney | RB | Minnesota |
| 2006 | 1 | 22 | SFO | Manny Lawson | DE | North Carolina St. |
| 2006 | 1 | 23 | TAM | Davin Joseph | G | Oklahoma |
| 2006 | 1 | 24 | CIN | Johnathan Joseph | DB | South Carolina |
| 2006 | 1 | 25 | PIT | Santonio Holmes | WR | Ohio St. |
| 2006 | 1 | 26 | BUF | John McCargo | DT | North Carolina St. |
| 2006 | 1 | 27 | CAR | DeAngelo Williams | RB | Memphis |
| 2006 | 1 | 28 | JAX | Marcedes Lewis | TE | UCLA |
| 2006 | 1 | 29 | NYJ | Nick Mangold | C | Ohio St. |
| 2006 | 1 | 30 | IND | Joseph Addai | RB | LSU |
| 2006 | 1 | 31 | SEA | Kelly Jennings | DB | Miami (FL) |
| 2006 | 1 | 32 | NYG | Mathias Kiwanuka | DE | Boston Col. |
