2005 NFL Draft Round 1
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 2005 | 1 | 1 | SFO | Alex Smith | QB | Utah |
| 2005 | 1 | 2 | MIA | Ronnie Brown | RB | Auburn |
| 2005 | 1 | 3 | CLE | Braylon Edwards | WR | Michigan |
| 2005 | 1 | 4 | CHI | Cedric Benson | RB | Texas |
| 2005 | 1 | 5 | TAM | Cadillac Williams | RB | Auburn |
| 2005 | 1 | 6 | TEN | Adam Jones | DB | West Virginia |
| 2005 | 1 | 7 | MIN | Troy Williamson | WR | South Carolina |
| 2005 | 1 | 8 | ARI | Antrel Rolle | DB | Miami (FL) |
| 2005 | 1 | 9 | WAS | Carlos Rogers | DB | Auburn |
| 2005 | 1 | 10 | DET | Mike Williams | WR | USC |
| 2005 | 1 | 11 | DAL | DeMarcus Ware | LB | Troy |
| 2005 | 1 | 12 | LAC | Shawne Merriman | LB | Maryland |
| 2005 | 1 | 13 | NOR | Jammal Brown | T | Oklahoma |
| 2005 | 1 | 14 | CAR | Thomas Davis | LB | Georgia |
| 2005 | 1 | 15 | KAN | Derrick Johnson | LB | Texas |
| 2005 | 1 | 16 | HOU | Travis Johnson | DT | Florida St. |
| 2005 | 1 | 17 | CIN | David Pollack | LB | Georgia |
| 2005 | 1 | 18 | MIN | Erasmus James | DE | Wisconsin |
| 2005 | 1 | 19 | RAM | Alex Barron | T | Florida St. |
| 2005 | 1 | 20 | DAL | Marcus Spears | DE | LSU |
| 2005 | 1 | 21 | JAX | Matt Jones | WR | Arkansas |
| 2005 | 1 | 22 | BAL | Mark Clayton | WR | Oklahoma |
| 2005 | 1 | 23 | LAS | Fabian Washington | DB | Nebraska |
| 2005 | 1 | 24 | GNB | Aaron Rodgers | QB | California |
| 2005 | 1 | 25 | WAS | Jason Campbell | QB | Auburn |
| 2005 | 1 | 26 | SEA | Chris Spencer | C | Mississippi |
| 2005 | 1 | 27 | ATL | Roddy White | WR | Ala-Birmingham |
| 2005 | 1 | 28 | LAC | Luis Castillo | DE | Northwestern |
| 2005 | 1 | 29 | IND | Marlin Jackson | DB | Michigan |
| 2005 | 1 | 30 | PIT | Heath Miller | TE | Virginia |
| 2005 | 1 | 31 | PHI | Mike Patterson | DT | USC |
| 2005 | 1 | 32 | NWE | Logan Mankins | G | Fresno St. |
