1988 NFL Draft Round 1
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 1988 | 1 | 1 | ATL | Aundray Bruce | LB | Auburn |
| 1988 | 1 | 2 | KAN | Neil Smith | DE | Nebraska |
| 1988 | 1 | 3 | DET | Bennie Blades | DB | Miami (FL) |
| 1988 | 1 | 4 | TAM | Paul Gruber | T | Wisconsin |
| 1988 | 1 | 5 | CIN | Rickey Dixon | DB | Oklahoma |
| 1988 | 1 | 6 | LAS | Tim Brown | WR | Notre Dame |
| 1988 | 1 | 7 | GNB | Sterling Sharpe | WR | South Carolina |
| 1988 | 1 | 8 | NYJ | Dave Cadigan | G | USC |
| 1988 | 1 | 9 | LAS | Terry McDaniel | DB | Tennessee |
| 1988 | 1 | 10 | NYG | Eric Moore | G | Indiana |
| 1988 | 1 | 11 | DAL | Michael Irvin | WR | Miami (FL) |
| 1988 | 1 | 12 | ARI | Ken Harvey | LB | California |
| 1988 | 1 | 13 | PHI | Keith Jackson | TE | Oklahoma |
| 1988 | 1 | 14 | RAM | Gaston Green | RB | UCLA |
| 1988 | 1 | 15 | LAC | Anthony Miller | WR | Tennessee |
| 1988 | 1 | 16 | MIA | Eric Kumerow | DE | Ohio St. |
| 1988 | 1 | 17 | NWE | John Stephens | RB | Northwestern St. (LA) |
| 1988 | 1 | 18 | PIT | Aaron Jones | DE | East. Kentucky |
| 1988 | 1 | 19 | MIN | Randall McDaniel | G | Arizona St. |
| 1988 | 1 | 20 | RAM | Aaron Cox | WR | Arizona St. |
| 1988 | 1 | 21 | CLE | Clifford Charlton | LB | Florida |
| 1988 | 1 | 22 | TEN | Lorenzo White | RB | Michigan St. |
| 1988 | 1 | 23 | CHI | Brad Muster | RB | Stanford |
| 1988 | 1 | 24 | NOR | Craig Heyward | RB | Pittsburgh |
| 1988 | 1 | 25 | LAS | Scott Davis | DT | Illinois |
| 1988 | 1 | 26 | DEN | Ted Gregory | NT | Syracuse |
| 1988 | 1 | 27 | CHI | Wendell Davis | WR | LSU |
