1969 NFL Draft Round 1
| YEAR | RND | PICK # | TEAM | PLAYER | POS | COLLEGE |
| 1969 | 1 | 1 | BUF | O.J. Simpson | RB | USC |
| 1969 | 1 | 2 | ATL | George Kunz | T | Notre Dame |
| 1969 | 1 | 3 | PHI | Leroy Keyes | DB | Purdue |
| 1969 | 1 | 4 | PIT | Joe Greene | DT | North Texas |
| 1969 | 1 | 5 | CIN | Greg Cook | QB | Cincinnati |
| 1969 | 1 | 6 | NWE | Ron Sellers | WR | Florida St. |
| 1969 | 1 | 7 | SFO | Ted Kwalick | TE | Penn St. |
| 1969 | 1 | 8 | RAM | Larry Smith | RB | Florida |
| 1969 | 1 | 9 | LAC | Marty Domres | QB | Columbia |
| 1969 | 1 | 10 | RAM | Jim Seymour | WR | Notre Dame |
| 1969 | 1 | 11 | MIA | Bill Stanfill | DE | Georgia |
| 1969 | 1 | 12 | GNB | Rich Moore | DT | Villanova |
| 1969 | 1 | 13 | NYG | Fred Dryer | DE | San Diego St. |
| 1969 | 1 | 14 | CHI | Rufus Mayes | T | Ohio St. |
| 1969 | 1 | 15 | TEN | Ron Pritchard | LB | Arizona St. |
| 1969 | 1 | 16 | SFO | Gene Washington | WR | Stanford |
| 1969 | 1 | 17 | NOR | John Shinners | G | Xavier (OH) |
| 1969 | 1 | 18 | LAC | Bob Babich | LB | Miami (OH) |
| 1969 | 1 | 19 | ARI | Roger Wehrli | DB | Missouri |
| 1969 | 1 | 20 | CLE | Ron Johnson | RB | Michigan |
| 1969 | 1 | 21 | RAM | Bob Klein | TE | USC |
| 1969 | 1 | 22 | LAS | Art Thoms | DT | Syracuse |
| 1969 | 1 | 23 | KAN | Jim Marsalis | DB | Tennessee St. |
| 1969 | 1 | 24 | DAL | Calvin Hill | RB | Yale |
| 1969 | 1 | 25 | IND | Eddie Hinton | WR | Oklahoma |
| 1969 | 1 | 26 | NYJ | Dave Foley | T | Ohio St. |
