With Week 15 of the 2025 NFL season fast approaching, sportsbooks have released the early point spreads, and several lopsided lines immediately stand out.
The largest favorites on the board include the Seattle Seahawks, laying 13.5 points at home against the Indianapolis Colts, along with the San Francisco 49ers and Jacksonville Jaguars, both favored by 12.5 over Tennessee and the New York Jets, respectively. The Philadelphia Eagles also headline the week as 11.5-point favorites at home against the Las Vegas Raiders. Overall, home teams dominate the early lines, holding a 12–4 advantage in favored matchups.
Below are the latest Week 15 point spread odds, beginning with Thursday night and running through Monday:
| 12/11 8:15 | Atlanta Falcons (4-9) at Tampa Bay Buccaneers (7-6) | TB -4.5 |
| 12/14 1:00 | Cleveland Browns (3-10) at Chicago Bears (9-4) | CHI -7.5 |
| 12/14 1:00 | Baltimore Ravens (6-7) at Cincinnati Bengals (4-9) | BAL -2.5 |
| 12/14 1:00 | Los Angeles Chargers (9-4) at Kansas City Chiefs (6-7) | KC -3.5 |
| 12/14 1:00 | Buffalo Bills (9-4) at New England Patriots (11-2) | BUF -1.5 |
| 12/14 1:00 | Washington Commanders (3-10) at New York Giants (2-11) | NYG -2.5 |
| 12/14 1:00 | Las Vegas Raiders (2-11) at Philadelphia Eagles (8-5) | PHI -11.5 |
| 12/14 1:00 | New York Jets (3-10) at Jacksonville Jaguars (9-4) | JAX -12.5 |
| 12/14 1:00 | Arizona Cardinals (3-10) at Houston Texans (8-5) | HOU -10 |
| 12/14 4:25 | Green Bay Packers (9-3-1) at Denver Broncos (11-2) | GB -2.5 |
| 12/14 4:25 | Detroit Lions (8-5) at Los Angeles Rams (10-3) | LAR -5.5 |
| 12/14 4:25 | Carolina Panthers (7-6) at New Orleans Saints (3-10) | CAR -2.5 |
| 12/14 4:25 | Tennessee Titans (2-11) at San Francisco 49ers (9-4) | SF -12.5 |
| 12/14 4:25 | Indianapolis Colts (8-5) at Seattle Seahawks (10-3) | SEA -13.5 |
| 12/14 8:20 | Minnesota Vikings (5-8) at Dallas Cowboys (6-6-1) | DAL -6 |
| 12/15 8:15 | Miami Dolphins (6-7) at Pittsburgh Steelers (7-6) | PIT -3 |