The NFL enters Week 13 with a holiday slate loaded with playoff implications and betting intrigue. The schedule kicks off Thursday with three Thanksgiving matchups, continues into Friday’s Black Friday showdown, and rolls through a jam-packed Sunday and Monday finish.
THANKSGIVING DAY — Thursday, November 27
1:00 PM — Packers (7-3-1) at Lions (7-4) — DET -2.5
Detroit is a slight home favorite in the holiday opener, and both teams enter above .500 against the spread (Lions 6-5 ATS, Packers 4-6-1 ATS). The Lions have been strong at home this year, while the Packers have struggled to cover on the road. Early bettors may note that underdogs have covered in 48.6% of games this season, nearly matching the favorites.
4:30 PM — Chiefs (6-5) at Cowboys (5-5-1) — KC -3
Kansas City is favored on the road despite a losing ATS record (5-6 ATS), while Dallas has been reliable at the window (6-5 ATS). The Cowboys have been inconsistent straight up but are trending as a home dog spot to watch, given favorites have been covering just 50.3% of the time league-wide.
8:20 PM — Bengals (3-8) at Ravens (6-5) — BAL -7
Baltimore enters as a strong TD favorite but has struggled relative to expectations at 5-6 ATS. Meanwhile, the Bengals are 4-7 ATS — one of the worst marks in the league. Large spreads have been historically risky this season: double-digit favorites cover only 38.5% of the time, which brings added intrigue to another near-touchdown line.
BLACK FRIDAY — Friday, November 28
3:00 PM — Bears (8-3) at Eagles (8-3) — PHI -7
The weekend’s marquee early matchup pits two 8-3 leaders. Philadelphia sits among the best against the spread (7-4 ATS), while Chicago is a respectable 6-5 ATS. With both teams above .500 straight-up and against the spread, this could be one of the most evenly handicapped heavyweight contests of the week.
SUNDAY & MONDAY — Full Week 13 Slate
The biggest spreads appear Sunday, with three matchups in particular drawing sharp attention:
Matchup Spread Notes:
- Rams at Panthers LAR -10.5 Rams are 8-3 ATS, tied for best in the NFL. Rare spot where a big favorite is also an elite ATS team.
- Vikings at Seahawks SEA -10.5 Seahawks also 8-3 ATS, matching the Rams for the league lead.
- Raiders at Chargers LAC -9.5 Chargers just 5-6 ATS, while Las Vegas is 4-7 ATS and struggling to compete.
The ATS elite continue to be the Rams (8-3), Seahawks (8-3), Colts (7-4), Jets (7-4) and Eagles (7-4). Notably, the four biggest Week 13 favorites include the two best ATS teams, making this a rare week where power rankings and betting performance align.
Other notable spreads:
- Broncos (9-2) at Commanders (3-8) — DEN -6.5
- Bills (7-4) at Steelers (6-5) — BUF -3.5
- Giants (2-10) at Patriots (10-2) — NE -7.5 (Patriots 7-5 ATS — most profitable of any double-digit win team)
League-wide Betting Notes
Through 178 games this season:
- Favorites ATS: 50.3%
- Underdogs ATS: 48.6%
- Home teams ATS: 51.0%
- Road teams ATS: 49.3%
- Overs vs. Unders: 89–89, perfectly 50/50
Trends by week have been volatile — unders have been dominant recently, with Week 12 seeing only 28.6% overs, while home favorites have cooled off significantly since Week 7.
Early Week 13 Takeaways
Thanksgiving slate is loaded with near pick’ems, each sitting at 7 points or fewer.
The Rams and Seahawks are the strongest ATS plays of the week, giving bettors unusually favorable alignment between spreads and team performance.
Be cautious with double-digit favorites — they cover only 38.5% of the time in 2025.
Overs and unders show no long-term lean, meaning game-specific analysis outweighs trend chasing this season.
Here are the latest point spread odds for week 13:
| 11/27 1:00 | Green Bay Packers (7-3-1) at Detroit Lions (7-4) | DET -2.5 |
| 11/27 4:30 | Kansas City Chiefs (6-5) at Dallas Cowboys (5-5-1) | KC -3 |
| 11/27 8:20 | Cincinnati Bengals (3-8) at Baltimore Ravens (6-5) | BAL -7 |
| 11/28 3:00 | Chicago Bears (8-3) at Philadelphia Eagles (8-3) | PHI -7 |
| 11/30 1:00 | San Francisco 49ers (8-4) at Cleveland Browns (3-8) | SF -5.5 |
| 11/30 1:00 | Jacksonville Jaguars (7-4) at Tennessee Titans (1-10) | JAX -6.5 |
| 11/30 1:00 | Houston Texans (6-5) at Indianapolis Colts (8-3) | IND -4.5 |
| 11/30 1:00 | New Orleans Saints (2-9) at Miami Dolphins (4-7) | MIA -6 |
| 11/30 1:00 | Atlanta Falcons (4-7) at New York Jets (2-9) | ATL -2.5 |
| 11/30 1:00 | Arizona Cardinals (3-8) at Tampa Bay Buccaneers (6-5) | TB -3 |
| 11/30 1:00 | Los Angeles Rams (9-2) at Carolina Panthers (6-6) | LAR -10.5 |
| 11/30 4:05 | Minnesota Vikings (4-7) at Seattle Seahawks (8-3) | SEA -10.5 |
| 11/30 4:25 | Buffalo Bills (7-4) at Pittsburgh Steelers (6-5) | BUF -3.5 |
| 11/30 4:25 | Las Vegas Raiders (2-9) at Los Angeles Chargers (7-4) | LAC -9.5 |
| 11/30 8:20 | Denver Broncos (9-2) at Washington Commanders (3-8) | DEN -6.5 |
| 12/1 8:15 | New York Giants (2-10) at New England Patriots (10-2) | NE -7.5 |