The early point spreads and lines for week three of the NFL season are available.
Here are biggest favorites for this week ahead: Miami Dolphins-Buffalo Bills (BUF by 11.5), Green Bay Packers-Cleveland Browns (GNB by 7.5), New Orleans Saints-Seattle Seahawks (SEA by 7.5) and the New York Jets-Tampa Bay Buccaneers (TAM by 6.5).
This week, the home teams have the overall betting numbers 10-5.
Here are the latest point spread odds for week 3:
| 9/18 8:15 | Miami Dolphins (0-2) at Buffalo Bills (2-0) | BUF -11.5 |
| 9/21 1:00 | Green Bay Packers (2-0) at Cleveland Browns (0-2) | GB -7.5 |
| 9/21 1:00 | Indianapolis Colts (2-0) at Tennessee Titans (0-2) | IND -3.5 |
| 9/21 1:00 | Cincinnati Bengals (2-0) at Minnesota Vikings (1-1) | MIN -2.5 |
| 9/21 1:00 | Pittsburgh Steelers (1-1) at New England Patriots (1-1) | PIT -1.5 |
| 9/21 1:00 | Los Angeles Rams (2-0) at Philadelphia Eagles (2-0) | PHI -3.5 |
| 9/21 1:00 | New York Jets (0-2) at Tampa Bay Buccaneers (2-0) | TB -6.5 |
| 9/21 1:00 | Las Vegas Raiders (1-1) at Washington Commanders (1-1) | WSH -3.5 |
| 9/21 1:00 | Atlanta Falcons (1-1) at Carolina Panthers (0-2) | ATL -5.5 |
| 9/21 1:00 | Houston Texans (0-2) at Jacksonville Jaguars (1-1) | JAX -1.5 |
| 9/21 4:05 | Denver Broncos (1-1) at Los Angeles Chargers (2-0) | LAC -2.5 |
| 9/21 4:05 | New Orleans Saints (0-2) at Seattle Seahawks (1-1) | SEA -7.5 |
| 9/21 4:25 | Dallas Cowboys (1-1) at Chicago Bears (0-2) | CHI -1.5 |
| 9/21 4:25 | Arizona Cardinals (2-0) at San Francisco 49ers (2-0) | SF -1.5 |
| 9/21 8:20 | Kansas City Chiefs (0-2) at New York Giants (0-2) | KC -5.5 |
| 9/22 8:15 | Detroit Lions (1-1) at Baltimore Ravens (1-1) | BAL -4.5 |