Christian McCaffrey of the San Francisco 49ers led the league with 83 rushes for first down during the 2023 NFL regular season. The 27-year-old was followed by Jalen Hurts (68), Derrick Henry (63) and then Kyren Williams (62)
2023 NFL Most Rushes For First Down (End of Regular Season)
Christian McCaffrey 83
Jalen Hurts 68
Derrick Henry 63
Kyren Williams 62
Chuba Hubbard 59
Joe Mixon 59
David Montgomery 59
Raheem Mostert 59
Josh Allen 57
James Conner 57
Tony Pollard 56
James Cook 53
Travis Etienne 53
Isiah Pacheco 53